Depicted is a model of the types of peripheral afferents that contribute to, or modify, the production of cough and their influence on the central components of the cough reflex. One candidate for this is dextromethorphan, and here the pharmacologic mechanism. Possible sites of action of peripherallyor centrallyactive antitussive drugs. Dextromethorphan dxm is a sigma1 and mu opioid receptor agonist with antagonist properties at nmda and nicotinic. Bhanu prakash usmle, fmge and neet pg recommended for you. Dextromethorphan is an uncompetitive nmethyldaspartate receptor antagonist and sigma1 agonist.
Suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Who expert committee on drug dependence, seventeenth report pdf. The mechanism of action of dextromethorphan is as an uncompetitive nmda. Dextromethorphan shows high affinity binding to several regions of the brain. Pdf mechanism of action of dextromethorphanquinidine. The precise molecular mechanism of action of dmq in each of these disparate conditions is unknown, and actions at more than one receptor or transporter. This emedtv resource further explores how dextromethorphan s mechanism of action may also help treat certain neurological problems. Dextromethorphan hydrobromide drug information, professional. It has multiple mechanisms of action, including actions as a nonselective serotonin reuptake inhibitor and a sigma1 receptor agonist.
By reducing the bodys reflex to cough, dextromethorphan can help to treat coughing due to a cold or flu. Dextromethorphan dxm or dm is a medication most often used as a cough suppressant in. It does not have addictive, analgesic or sedative action and in usual doses does not produce respiratory depression or inhibit ciliary activity. Pharmacologic mechanism of action of dextromethorphan the pharmacologic actions of dextromethorphan are showninfigure1b.
There is animal evidence indicating that at least some of dextromethorphans antidepressant actions involve sigma1 receptors 57. Pdf mechanisms of action of central and peripheral. Its mechanism of action is as an nmda receptor antagonist, producing effects similar to those of ketamine and phencyclidine pcp. Mechanism of action dextromethorphan hydrobromide is a semisynthetic derivative of opium that acts centrally to elevate the cough threshold.
84 55 975 869 1265 863 1105 969 1341 1178 1194 1335 732 907 339 1455 353 298 802 1257 1490 15 1037 363 126 375 1310 541 1197 1427 447 1412 34 959 632 1144 490 553 1118 1124 316 294 899 1270 438 1403 374